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Gary K Scott Selected Research

Breast Neoplasms (Breast Cancer)

1/2019Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition.
10/2017ERpS294 is a biomarker of ligand or mutational ERĪ± activation and a breast cancer target for CDK2 inhibition.
7/2014RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.
1/2014Sources of superoxide/H2O2 during mitochondrial proline oxidation.
8/2012Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.
5/2009Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.
3/2009Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites.
2/2009Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis.
7/2008Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6.
5/2008A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells.
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Gary K Scott Research Topics

Disease

22Neoplasms (Cancer)
12/2021 - 04/2002
22Breast Neoplasms (Breast Cancer)
01/2019 - 04/2002
2Neurodegenerative Diseases (Neurodegenerative Disease)
12/2023 - 12/2021
2Carcinogenesis
12/2005 - 01/2005
1Hyperoxaluria (Oxaluria)
01/2024
1Huntington Disease (Huntington's Disease)
12/2023
1Alzheimer Disease (Alzheimer's Disease)
12/2023
1Disease Progression
12/2023
1Parkinson Disease (Parkinson's Disease)
12/2023
1Noninfiltrating Intraductal Carcinoma (DCIS)
05/2009
1Ductal Carcinoma
05/2009
1Neoplasm Metastasis (Metastasis)
02/2009
1Infections
01/2007
1Prostatic Neoplasms (Prostate Cancer)
06/2006
1Hypersensitivity (Allergy)
04/2002

Drug/Important Bio-Agent (IBA)

11Estrogen ReceptorsIBA
08/2012 - 12/2002
8Proteins (Proteins, Gene)FDA Link
07/2014 - 09/2003
6Hormones (Hormone)IBA
06/2013 - 12/2002
5DNA (Deoxyribonucleic Acid)IBA
04/2007 - 12/2002
4Proline Oxidase (Proline Dehydrogenase)IBA
12/2023 - 01/2014
4Messenger RNA (mRNA)IBA
01/2019 - 06/2006
4Histone Deacetylase InhibitorsIBA
05/2009 - 04/2002
3propargylglycineIBA
01/2024 - 01/2019
3Biomarkers (Surrogate Marker)IBA
10/2017 - 06/2006
3LigandsIBA
10/2017 - 01/2006
3Transcription Factors (Transcription Factor)IBA
08/2012 - 12/2005
3MicroRNAs (MicroRNA)IBA
01/2007 - 02/2006
2FlavoproteinsIBA
12/2021 - 01/2019
2TubulinIBA
07/2014 - 05/2009
2Cyclin D1IBA
07/2014 - 06/2006
2Estradiol (Delestrogen)FDA LinkGeneric
08/2012 - 03/2009
2NF-kappa B (NF-kB)IBA
02/2009 - 05/2005
2Serine (L-Serine)FDA Link
05/2008 - 09/2005
2Bortezomib (Velcade)FDA Link
06/2007 - 06/2006
2Oxidants (Oxidizing Agents)IBA
09/2003 - 12/2002
1Antineoplastic Agents (Antineoplastics)IBA
12/2021
1AcidsIBA
01/2019
1Adenosine Triphosphate (ATP)IBA
01/2019
1GlutaminaseIBA
01/2019
1Glutamic Acid (Glutamate)FDA Link
01/2019
1palbociclibIBA
10/2017
1dinaciclibIBA
10/2017
1SurvivinIBA
07/2014
1Proline (L-Proline)FDA Link
01/2014
1Oxygen (Dioxygen)IBA
01/2014
1Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA
01/2014
1TamoxifenFDA LinkGeneric
08/2012
1Epidermal Growth Factor (EGF)IBA
08/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2012
1Neuregulin-1 (Neuregulin 1)IBA
08/2012
1Insulin (Novolin)FDA Link
08/2012
1Conditioned Culture MediaIBA
10/2009
1CytokinesIBA
10/2009
1Histone Deacetylases (Histone Deacetylase)IBA
05/2009
1Histones (Histone)IBA
05/2009
1Nuclear Proteins (Protein, Nuclear)IBA
02/2009
1ErbB Receptors (EGF Receptor)IBA
02/2009
1ElementsIBA
07/2008
13' Untranslated Regions (3' UTR)IBA
07/2008
1RNA (Ribonucleic Acid)IBA
07/2008
1Estrogen Receptor alphaIBA
05/2008
1UbiquitinIBA
06/2007
1PeptidomimeticsIBA
06/2007
1Peptide Hydrolases (Proteases)FDA Link
06/2007
1Proteasome Endopeptidase Complex (Proteasome)IBA
06/2007
1Tumor Biomarkers (Tumor Markers)IBA
06/2006
1LuciferasesIBA
06/2006
1Proteasome InhibitorsIBA
06/2006
1Trastuzumab (Herceptin)FDA Link
06/2006
1Hydroxamic Acids (Hydroxamic Acid)IBA
02/2006
1LAQ824IBA
02/2006
1quinone (benzoquinone)IBA
01/2006
1Protein Isoforms (Isoforms)IBA
12/2005
1Mitogen-Activated Protein KinasesIBA
09/2005
1Keratin-8 (Keratin 8)IBA
09/2005
1NAD (NADH)IBA
01/2005
1Cysteine (L-Cysteine)FDA Link
09/2003
1Cathepsin DIBA
12/2002
1EnzymesIBA
12/2002
1Protein Kinases (Protein Kinase)IBA
12/2002
1theasinensin AIBA
04/2002
1ChromatinIBA
04/2002
1Butyric Acid (Butanoic Acid)IBA
04/2002
1Deoxyribonuclease I (Nickase)IBA
04/2002
1trichostatin A (A 300)IBA
04/2002

Therapy/Procedure

5Therapeutics
12/2023 - 04/2002
1Mammaplasty (Breast Reconstruction)
05/2009